The Hydrobiome Serum is a lightweight, microbiome-balancing treatment designed to calm inflammation, strengthen the skin barrier, and restore healthier skin function (without harsh actives or drying ingredients).

What it Is: A lightweight microbiome-support serum designed to calm irritation, strengthen the skin barrier, and restore balance to reactive or acne-prone skin.
What it Does: Helps reduce visible redness, support the skin’s natural microbiome, and reinforce barrier health while improving overall skin resilience.
Why this formula is different: Most blemish treatments focus on suppressing oil or aggressively targeting bacteria. Hydrobiome takes a completely different approach by working with the skin’s ecosystem to restore balance. Powered by two clinically proven actives:
- TCP (TLR2 Modulator) – a patented ingredient developed by Signum Biosciences that helps calm irritation while regulating inflammatory signaling and microbiome balance.
- TPNa (Water-Soluble Vitamin E) – delivers antioxidant protection while strengthening the skin barrier and reducing visible redness.
- Sodium Hyaluronate – boosts hydration and improves skin comfort.
What Makes it Special: Powered by TCP, a patented microbiome-modulating ingredient, this formula helps limit the growth of harmful bacteria that contribute to breakouts and inflammation while working with the skin to restore balance. TPNa, a stabilized form of Vitamin E, delivers antioxidant protection while helping strengthen the skin barrier and reduce signs of irritation. The result is calmer, more balanced skin without the dryness often associated with traditional blemish-focused treatments.

Ingredients:

Water, Propanediol, Pentylene Glycol, Glycerin, Disodium Tetramethylhexadecenylcysteine Formylprolinate, Sodium Tocopheryl Phosphate, Sodium Hyaluronate, Sodium Phytate, Carbomer, Potassium Hydroxide

How to Apply:

Apply 1–2 pumps to clean skin morning and evening. Gently press into the face and neck. Follow with moisturizer and SPF during the day.